In utero irradiation - induced alterations in the mouse brain characterised by 3 D T 2 - weighted MRI
نویسندگان
چکیده
Send this abstract to [email protected] 1 In utero irradiation-induced alterations in the mouse brain characterised by 3D T2weighted MRI Tine Verreet, Janaki Raman Rangarajan, Uwe Himmelreich, Frederik Maes, Roel Quintens, Mieke Verslegers, Sarah Baatout, Lieve Moons, Mohammed Abderrafi Benotmane [email protected] Laboratory of Molecular and Cellular Biology, Belgian Nuclear Research Centre, SCK•CEN, Belgium Laboratory of Neural Circuit Development and Regeneration, KU Leuven, Belgium Medical Image Computing, Department of Electrical Engineering (ESAT/PSI), KU Leuven, Belgium iMinds Medical IT Department, KU Leuven, Belgium Biomedical MRI Unit, KU Leuven, Belgium Molecular Small Animal Imaging Centre (MoSAIC), KU Leuven, Belgium
منابع مشابه
MRI evaluation of rabbit bone marrow after acute irradiation
Background: Magnetic Resonance Imaging (MRI) is a safe modality and useful in characterizing normal and abnormal bone marrow (BM). MRI also presents a more global view of BM than biopsy therefore, it may provide a better understanding of hematologic disorders. The purpose of this study was to monitor radiation-induced alterations of BM in acute phase of irradiation (1-10 day after total body ir...
متن کاملPersistent Impact of In utero Irradiation on Mouse Brain Structure and Function Characterized by MR Imaging and Behavioral Analysis
Prenatal irradiation is known to perturb brain development. Epidemiological studies revealed that radiation exposure during weeks 8-15 of pregnancy was associated with an increased occurrence of mental disability and microcephaly. Such neurological deficits were reproduced in animal models, in which rodent behavioral testing is an often used tool to evaluate radiation-induced defective brain fu...
متن کاملDiffusion MRI of in utero mouse embryos
Introduction The mouse embryo is a widespread animal model for human development disorders. MRI offers a unique, noninvasive approach for imaging normal and abnormal mouse embryo development in later gestational stages. One of the difficulties of imaging in utero mouse embryos is the lack of tissue contrast exhibited by the embryo at high magnet field strengths. This project explores the use of...
متن کاملBrain Volume Estimation Enhancement by Morphological Image Processing Tools
Background: Volume estimation of brain is important for many neurological applications. It is necessary in measuring brain growth and changes in brain in normal/abnormal patients. Thus, accurate brain volume measurement is very important. Magnetic resonance imaging (MRI) is the method of choice for volume quantification due to excellent levels of image resolution and between-tissue contrast. St...
متن کاملOxidative membrane damage and its involvement in gamma radiation-induced apoptotic cell death.
Background: Recent results have provided increasing evidence to support involvement of membrane damage in the mechanism of ionizing radiation induced killing of mammalian cells. These findings have stimulated renewed interest in evaluating the damage to membrane as a primary initiator in radiation-induced cell killing especially in apoptotic death. The present study was aimed to gain deeper ins...
متن کامل